Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test.
Identifieur interne : 000763 ( Main/Exploration ); précédent : 000762; suivant : 000764Evidence for the involvement of extinction-associated inhibitory learning in the forced swimming test.
Auteurs : P. Campus [Italie] ; V. Colelli [Italie] ; C. Orsini [Italie] ; D. Sarra [Italie] ; S. Cabib [Italie]Source :
- Behavioural brain research [ 1872-7549 ] ; 2015.
Descripteurs français
- KwdFr :
- Agonistes du récepteur GABA-A (pharmacologie), Amygdale (système limbique) (), Amygdale (système limbique) (physiologie), Analyse de variance, Animaux, Apprentissage associatif (physiologie), Apprentissage du labyrinthe (), Extinction (psychologie) (), Extinction (psychologie) (physiologie), Inhibition nerveuse (), Inhibition nerveuse (physiologie), Latéralité fonctionnelle (), Muscimol (pharmacologie), Mâle, Natation (psychologie), Souris, Souris de lignée DBA, Temps de réaction ().
- MESH :
- pharmacologie : Agonistes du récepteur GABA-A, Muscimol.
- physiologie : Amygdale (système limbique), Apprentissage associatif, Extinction (psychologie), Inhibition nerveuse.
- psychologie : Natation.
- Amygdale (système limbique), Analyse de variance, Animaux, Apprentissage du labyrinthe, Extinction (psychologie), Inhibition nerveuse, Latéralité fonctionnelle, Mâle, Souris, Souris de lignée DBA, Temps de réaction.
English descriptors
- KwdEn :
- Amygdala (drug effects), Amygdala (physiology), Analysis of Variance, Animals, Association Learning (physiology), Extinction, Psychological (drug effects), Extinction, Psychological (physiology), Functional Laterality (drug effects), GABA-A Receptor Agonists (pharmacology), Male, Maze Learning (drug effects), Mice, Mice, Inbred DBA, Muscimol (pharmacology), Neural Inhibition (drug effects), Neural Inhibition (physiology), Reaction Time (drug effects), Swimming (psychology).
- MESH :
- chemical , pharmacology : GABA-A Receptor Agonists, Muscimol.
- drug effects : Amygdala, Extinction, Psychological, Functional Laterality, Maze Learning, Neural Inhibition, Reaction Time.
- physiology : Amygdala, Association Learning, Extinction, Psychological, Neural Inhibition.
- psychology : Swimming.
- Analysis of Variance, Animals, Male, Mice, Mice, Inbred DBA.
Abstract
The forced swimming test (FST) remains one of the most used tools for screening antidepressants in rodent models. Nonetheless, the nature of immobility, its main behavioral measure, is still a matter of debate. The present study took advantage of our recent finding that mice of the inbred DBA/2J strain require a functioning left dorsolateral striatum (DLS) to consolidate long-term memory of FST to test whether immobility is the outcome of stress-related learning. Infusion of the GABA-A agonist muscimol in the left DLS immediately after a single experience of FST prevented and infusion in the left or the right amygdala impaired recall of the acquired levels of immobility in a probe test performed 24h later. Post-training left DLS infusion of muscimol, at a dose capable of preventing retention of FST-induced immobility, did not influence 24h retention of inhibitory avoidance training or of the escape response acquired in a water T-maze. However, this same treatment prevented 24h retention of the extinction training of the consolidated escape response. These results indicate that a left DLS-centered memory system selectively mediates memory consolidation of FST and of escape extinction and support the hypothesis that immobility is the result of extinction-like inhibitory learning involving all available escape responses due to the inescapable/unavoidable nature of FST experience.
DOI: 10.1016/j.bbr.2014.10.009
PubMed: 25448432
Affiliations:
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Campus</name><affiliation wicri:level="1"><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome</wicri:regionArea><wicri:noRegion>I-00143 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Colelli, V" sort="Colelli, V" uniqKey="Colelli V" first="V" last="Colelli">V. Colelli</name><affiliation wicri:level="1"><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome</wicri:regionArea><wicri:noRegion>I-00185 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Orsini, C" sort="Orsini, C" uniqKey="Orsini C" first="C" last="Orsini">C. Orsini</name><affiliation wicri:level="1"><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome</wicri:regionArea><wicri:noRegion>I-00143 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Sarra, D" sort="Sarra, D" uniqKey="Sarra D" first="D" last="Sarra">D. Sarra</name><affiliation wicri:level="1"><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome</wicri:regionArea><wicri:noRegion>I-00185 Rome</wicri:noRegion></affiliation></author><author><name sortKey="Cabib, S" sort="Cabib, S" uniqKey="Cabib S" first="S" last="Cabib">S. Cabib</name><affiliation wicri:level="1"><nlm:affiliation>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome, Italy. Electronic address: simona.cabib@uniroma1.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dip. Psicologia, Center D.Bovet (CRIN), 'Sapienza' University of Rome, via dei Marsi 78, I-00185 Rome, Italy; Fondazione Santa Lucia I.R.C.C.S., Via del Fosso di Fiorano 64, I-00143 Rome</wicri:regionArea><wicri:noRegion>I-00143 Rome</wicri:noRegion></affiliation></author></analytic><series><title level="j">Behavioural brain research</title><idno type="eISSN">1872-7549</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amygdala (drug effects)</term><term>Amygdala (physiology)</term><term>Analysis of Variance</term><term>Animals</term><term>Association Learning (physiology)</term><term>Extinction, Psychological (drug effects)</term><term>Extinction, Psychological (physiology)</term><term>Functional Laterality (drug effects)</term><term>GABA-A Receptor Agonists (pharmacology)</term><term>Male</term><term>Maze Learning (drug effects)</term><term>Mice</term><term>Mice, Inbred DBA</term><term>Muscimol (pharmacology)</term><term>Neural Inhibition (drug effects)</term><term>Neural Inhibition (physiology)</term><term>Reaction Time (drug effects)</term><term>Swimming (psychology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agonistes du récepteur GABA-A (pharmacologie)</term><term>Amygdale (système limbique) ()</term><term>Amygdale (système limbique) (physiologie)</term><term>Analyse de variance</term><term>Animaux</term><term>Apprentissage associatif (physiologie)</term><term>Apprentissage du labyrinthe ()</term><term>Extinction (psychologie) ()</term><term>Extinction (psychologie) (physiologie)</term><term>Inhibition nerveuse ()</term><term>Inhibition nerveuse (physiologie)</term><term>Latéralité fonctionnelle ()</term><term>Muscimol (pharmacologie)</term><term>Mâle</term><term>Natation (psychologie)</term><term>Souris</term><term>Souris de lignée DBA</term><term>Temps de réaction ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>GABA-A Receptor Agonists</term><term>Muscimol</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Amygdala</term><term>Extinction, Psychological</term><term>Functional Laterality</term><term>Maze Learning</term><term>Neural Inhibition</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agonistes du récepteur GABA-A</term><term>Muscimol</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Amygdale (système limbique)</term><term>Apprentissage associatif</term><term>Extinction (psychologie)</term><term>Inhibition nerveuse</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Amygdala</term><term>Association Learning</term><term>Extinction, Psychological</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Natation</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Swimming</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred DBA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Amygdale (système limbique)</term><term>Analyse de variance</term><term>Animaux</term><term>Apprentissage du labyrinthe</term><term>Extinction (psychologie)</term><term>Inhibition nerveuse</term><term>Latéralité fonctionnelle</term><term>Mâle</term><term>Souris</term><term>Souris de lignée DBA</term><term>Temps de réaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The forced swimming test (FST) remains one of the most used tools for screening antidepressants in rodent models. Nonetheless, the nature of immobility, its main behavioral measure, is still a matter of debate. The present study took advantage of our recent finding that mice of the inbred DBA/2J strain require a functioning left dorsolateral striatum (DLS) to consolidate long-term memory of FST to test whether immobility is the outcome of stress-related learning. Infusion of the GABA-A agonist muscimol in the left DLS immediately after a single experience of FST prevented and infusion in the left or the right amygdala impaired recall of the acquired levels of immobility in a probe test performed 24h later. Post-training left DLS infusion of muscimol, at a dose capable of preventing retention of FST-induced immobility, did not influence 24h retention of inhibitory avoidance training or of the escape response acquired in a water T-maze. However, this same treatment prevented 24h retention of the extinction training of the consolidated escape response. These results indicate that a left DLS-centered memory system selectively mediates memory consolidation of FST and of escape extinction and support the hypothesis that immobility is the result of extinction-like inhibitory learning involving all available escape responses due to the inescapable/unavoidable nature of FST experience.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Campus, P" sort="Campus, P" uniqKey="Campus P" first="P" last="Campus">P. Campus</name></noRegion><name sortKey="Cabib, S" sort="Cabib, S" uniqKey="Cabib S" first="S" last="Cabib">S. Cabib</name><name sortKey="Colelli, V" sort="Colelli, V" uniqKey="Colelli V" first="V" last="Colelli">V. Colelli</name><name sortKey="Orsini, C" sort="Orsini, C" uniqKey="Orsini C" first="C" last="Orsini">C. Orsini</name><name sortKey="Sarra, D" sort="Sarra, D" uniqKey="Sarra D" first="D" last="Sarra">D. Sarra</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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